Astrocyte heterogeneity: impact to brain aging and disease

I Matias, J Morgado, FCA Gomes - Frontiers in aging neuroscience, 2019 - frontiersin.org
Astrocytes, one of the largest glial cell population in the central nervous system (CNS), play
a key function in several events of brain development and function, such as synapse …

Functional diversity of astrocytes in neural circuit regulation

LB Haim, DH Rowitch - Nature Reviews Neuroscience, 2017 - nature.com
Although it is well established that all brain regions contain various neuronal subtypes with
different functions, astrocytes have traditionally been thought to be homogenous. However …

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

SW Bothwell, D Janigro, A Patabendige - Fluids and Barriers of the CNS, 2019 - Springer
The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …

Tripartite synapses: glia, the unacknowledged partner

A Araque, V Parpura, RP Sanzgiri, PG Haydon - Trends in neurosciences, 1999 - cell.com
According to the classical view of the nervous system, the numerically superior glial cells
have inferior roles in that they provide an ideal environment for neuronal-cell function …

Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains

EA Bushong, ME Martone, YZ Jones… - Journal of …, 2002 - Soc Neuroscience
Protoplasmic astrocytes are increasingly thought to interact extensively with neuronal
elements in the brain and to influence their activity. Recent reports have also begun to …

Astroglial networks: a step further in neuroglial and gliovascular interactions

C Giaume, A Koulakoff, L Roux, D Holcman… - Nature Reviews …, 2010 - nature.com
Dynamic aspects of interactions between astrocytes, neurons and the vasculature have
recently been in the neuroscience spotlight. It has emerged that not only neurons but also …

Astrocyte heterogeneity: an underappreciated topic in neurobiology

Y Zhang, BA Barres - Current opinion in neurobiology, 2010 - Elsevier
Astrocytes, one of the most numerous types of cells in the central nervous system, are crucial
for potassium homeostasis, neurotransmitter uptake, synapse formation, regulation of blood …

Targeting LDH enzymes with a stiripentol analog to treat epilepsy

N Sada, S Lee, T Katsu, T Otsuki, T Inoue - Science, 2015 - science.org
Neuronal excitation is regulated by energy metabolism, and drug-resistant epilepsy can be
suppressed by special diets. Here, we report that seizures and epileptiform activity are …

Heterogeneity of the blood-brain barrier

I Wilhelm, Á Nyúl-Tóth, M Suciu, A Hermenean… - Tissue …, 2016 - Taylor & Francis
The brain microvascular network is comprised of capillaries, arterioles and venules, all of
which retain–although to a different extent–blood-brain barrier (BBB) properties. Capillaries …

The glial identity of neural stem cells

F Doetsch - Nature neuroscience, 2003 - nature.com
Glia are the most numerous cells in the brain, and their many diverse functions highlight
their essential role in the nervous system. Recent studies have revealed an unexpected new …