Many cell functions are regulated by members of the cytokine receptor superfamily.
Signalling by these receptors depends upon their association with Janus kinases (JAKs) …

Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal
transduction pathways that govern cellular survival, proliferation, differentiation and …

The Janus family of tyrosine kinases (JAK) plays an essential role in development and in
coupling cytokine receptors to downstream intracellular signaling events. A t (9; 12)(p24; …

Random phage display peptide libraries and affinity selective methods were used to isolate
small peptides that bind to and activate the receptor for the cytokine erythropoietin (EPO). In …

Many cytokines mediate their biological effects through interaction with a distinct family of
receptors termed the cytokine receptor superfamily. Although members of this family lack …

THE peptide angiotensin II is the effector molecule of the renin-angiotensin system. All the
haemodynamic effects of angiotensin II, including vasoconstriction and adrenal aldosterone …

Erythropoietin receptor (EPOR) is thought to be activated by ligand-induced
homodimerization. However, structures of agonist and antagonist peptide complexes of …

Hematopoiesis is regulated through the interaction of a variety of growth factors with specific
receptors of the cytokine receptor superfamily. Although lacking catalytic domains, all the …

The high-affinity receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF)
consists of a unique α chain and a β c subunit that is shared with the receptors for interleukin …

We show that Janus kinase 2 (JAK2), and more specifically just its intact N-terminal domain,
binds to the erythropoietin receptor (EpoR) in the endoplasmic reticulum and promotes its …