Toolbox for distal C–H bond functionalizations in organic molecules

SK Sinha, S Guin, S Maiti, JP Biswas, S Porey… - Chemical …, 2021 - ACS Publications
Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

C–H activation

T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Stereodynamic strategies to induce and enrich chirality of atropisomers at a late stage

CB Roos, CH Chiang, LAM Murray, D Yang… - Chemical …, 2023 - ACS Publications
Enantiomers, where chirality arises from restricted rotation around a single bond, are
atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to …

Recent development in transition metal-catalysed C–H olefination

W Ali, G Prakash, D Maiti - Chemical Science, 2021 - pubs.rsc.org
Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds
represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of …

Pd-catalyzed regioselective activation of C (sp 2)–H and C (sp 3)–H bonds

W Ali, GA Oliver, DB Werz, D Maiti - Chemical Society Reviews, 2024 - pubs.rsc.org
Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

Palladium-Catalyzed Regioselective B(9)-Amination of o-Carboranes and m-Carboranes in HFIP with Broad Nitrogen Sources

YN Ma, Y Gao, Y Ma, Y Wang, H Ren… - Journal of the American …, 2022 - ACS Publications
Amination of carboranes has a good application prospect in organic and pharmaceutical
synthesis. However, the current methods used for this transformation suffer from limitations …

Photochemical intermolecular dearomative cycloaddition of bicyclic azaarenes with alkenes

J Ma, S Chen, P Bellotti, R Guo, F Schäfer, A Heusler… - Science, 2021 - science.org
Dearomative cycloaddition reactions represent an ideal means of converting flat arenes into
three-dimensional architectures of increasing interest in medicinal chemistry. Quinolines …

Chiral transient directing groups in transition-metal-catalyzed enantioselective C–H bond functionalization

MI Lapuh, S Mazeh, T Besset - ACS Catalysis, 2020 - ACS Publications
Transition-metal-catalyzed C–H bond functionalization has known a rapid evolution in the
last years, offering modern strategies for reaching high molecular complexity in a step-and …

Empirical guidelines for the development of remote directing templates through quantitative and experimental analyses

NYS Lam, Z Fan, K Wu, HS Park, SY Shim… - Journal of the …, 2022 - ACS Publications
The ability to differentiate and selectively activate remote C–H bonds represents a perennial
challenge in the field of C–H activation. Since its first report in 2012, a now-established …

Atropoenantioselective palladaelectro-catalyzed anilide C–H olefinations viable with natural sunlight as sustainable power source

J Frey, X Hou, L Ackermann - Chemical Science, 2022 - pubs.rsc.org
Enantioselective electrocatalyzed transformations represent a major challenge. We herein
achieved atropoenantioselective pallada-electrocatalyzed C–H olefinations and C–H …