Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets

R Li, Y Li, X Liang, L Yang, M Su… - Briefings in …, 2021 - academic.oup.com
Objectives Patients with colorectal cancer (CRC) may be susceptible to the coronavirus
disease-2019 (COVID-19). However, anti-CRC/COVID-19 treatment options are currently …

[HTML][HTML] Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19

R Li, K Wu, Y Li, X Liang, WKF Tse, L Yang… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), an epidemic disease characterized by rapid infection and a high …

Integrative pharmacological mechanism of vitamin C combined with glycyrrhizic acid against COVID-19: findings of bioinformatics analyses

R Li, K Wu, Y Li, X Liang, KP Lai… - Briefings in …, 2021 - academic.oup.com
Abstract Objective Coronavirus disease 2019 (COVID-19) is a fatal and fast-spreading viral
infection. To date, the number of COVID-19 patients worldwide has crossed over six million …

Anti–coronavirus disease 2019 (COVID‐19) targets and mechanisms of puerarin

X Qin, C Huang, K Wu, Y Li, X Liang… - Journal of cellular and …, 2021 - Wiley Online Library
The present study aimed to uncover the pharmacological function and underlying
mechanism of puerarin as a potential treatment for COVID‐19, using an in silico …

Therapeutic target and molecular mechanism of vitamin C-treated pneumonia: a systematic study of network pharmacology

R Li, C Guo, Y Li, X Liang, L Yang, W Huang - Food & function, 2020 - pubs.rsc.org
Vitamin C (VC), a well-reported antioxidant, is found with beneficial actions of preventing
and treating pneumonia. However, the detailed pharmacological target and mechanism of …

Anti-colorectal cancer biotargets and biological mechanisms of puerarin: study of molecular networks

J Li, C Guo, X Lu, W Tan - European Journal of Pharmacology, 2019 - Elsevier
Based on network pharmacology analysis, this study was to uncover the anti-colorectal
cancer (CRC) targets and molecular mechanisms exerted by puerarin. Pathological genes …

Integrated analysis reveals the targets and mechanisms in immunosuppressive effect of mesalazine on ulcerative colitis

R Li, X Huang, L Yang, X Liang, W Huang, KP Lai… - Frontiers in …, 2022 - frontiersin.org
Background Ulcerative colitis (UC) is an inflammatory bowel disease that causes
inflammation and ulcers in the digestive tract. Approximately 3 million US adults suffer from …

Targets of vitamin C with therapeutic potential for cardiovascular disease and underlying mechanisms: a study of network pharmacology

N Zhu, B Huang, W Jiang - Frontiers in pharmacology, 2021 - frontiersin.org
Vitamin C (ascorbic acid) is a nutrient used to treat cardiovascular disease (CVD). However,
the pharmacological targets of vitamin C and the mechanisms underlying the therapeutic …

Curcumol: a review of its pharmacology, pharmacokinetics, drug delivery systems, structure–activity relationships, and potential applications

S Zhai, R Wang, J Wang, X Xu, L Niu, M Guo… - …, 2024 - Springer
Abstract Curcumol (Cur), a guaiane-type sesquiterpenoid hemiketal, is an important and
representative bioactive component extracted from the essential oil of the rhizomes of …

[HTML][HTML] Therapeutic targets and molecular mechanism of calycosin for the treatment of cerebral ischemia/reperfusion injury

S Yu, K Wu, Y Liang, H Zhang, C Guo, B Yang - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
This study was designed to understand the pivotal anti-cerebral ischemia/reperfusion injury
(CIRI) targets and pathways of calycosin through network pharmacology and molecular …