Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

In vitro chemical safety testing methods offer the potential for efficient and economical tools
to provide relevant assessments of human health risk. To realize this potential, methods are …

Despite an abundance of online databases providing access to chemical data, there is
increasing demand for high-quality, structure-curated, open data to meet the various needs …

Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …

Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …

Tens-of-thousands of chemicals are registered in the US for use in countless processes and
products. Recent evidence suggests that many of these chemicals are measureable in …

Disinfection of surfaces has been recommended as one of the most effective ways to combat
the spread of novel coronavirus (SARS-CoV-2) that causes coronavirus disease 2019 …

Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …

During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

An important goal in toxicology is the development of new ways to increase the speed,
accuracy, and applicability of chemical hazard and risk assessment approaches. A …