Human pathophysiological adaptations to the space environment

GC Demontis, MM Germani, EG Caiani… - Frontiers in …, 2017 - frontiersin.org
Space is an extreme environment for the human body, where during long-term missions
microgravity and high radiation levels represent major threats to crew health. Intriguingly …

Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro

B Prasad, D Grimm, SM Strauch, GS Erzinger… - International journal of …, 2020 - mdpi.com
All life forms have evolved under the constant force of gravity on Earth and developed ways
to counterbalance acceleration load. In space, shear forces, buoyance-driven convection …

The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Modeling the impact of microgravity at the cellular level: implications for human disease

P Bradbury, H Wu, JU Choi, AE Rowan… - Frontiers in cell and …, 2020 - frontiersin.org
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Growing tissues in real and simulated microgravity: new methods for tissue engineering

D Grimm, M Wehland, J Pietsch… - … Engineering Part B …, 2014 - liebertpub.com
Tissue engineering in simulated (s-) and real microgravity (r-μ g) is currently a topic in Space
medicine contributing to biomedical sciences and their applications on Earth. The principal …

Using space-based investigations to inform cancer research on Earth

JL Becker, GR Souza - Nature Reviews Cancer, 2013 - nature.com
Experiments conducted in the microgravity environment of space are not typically at the
forefront of the mind of a cancer biologist. However, space provides physical conditions that …

Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells

MZ Nassef, S Kopp, M Wehland, D Melnik… - International journal of …, 2019 - mdpi.com
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …

Alterations of the cytoskeleton in human cells in space proved by life-cell imaging

TJ Corydon, S Kopp, M Wehland, M Braun, A Schütte… - Scientific reports, 2016 - nature.com
Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …

A 3D‐bioprinted vascularized glioblastoma‐on‐a‐chip for studying the impact of simulated microgravity as a novel pre‐clinical approach in brain tumor therapy

G Silvani, C Basirun, H Wu, C Mehner… - Advanced …, 2021 - Wiley Online Library
Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and
urgently requires the development of new therapeutic strategies. In this study, an innovative …