Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the
view of cancer as a tumor cell-centric disease. The tumor microenvironment, especially …

The adenomatous polyposis coli (APC) gene, known as tumor suppressor gene, has the two
promoters 1A and 1B. Researches on APC have usually focused on its loss-of-function …

Senescent microenvironments play an important role in tumor progression. Here, we report
that doxorubicin (DOX)‐pretreated or replicative senescent stromal cells (WI‐38 and …

Simple Summary In this review article, we will deepen the topic of cancer cell
communication with the surrounding non-cancerous cells. In particular, the non-mutational …

Colorectal cancer (CRC)-associated senescent fibroblasts may play a crucial role in tumor
progression, but the mechanism remains unclear. In order to solve this complicated problem …

Colorectal cancer (CRC) is one of the most common diseases in people throughout the
world, and it's been linked to a series of genetic abnormalities in normal colon epithelial …

Buněčná senescence je definována jako ireverzibilní zástava buněčného cyklu způsobená
různými faktory a procesy, které činí životaschopné a fungující buňky nefunkčními, což brání …