The pattern of delayed recurrence in a subset of breast cancer patients has long been
explained by a model that incorporates a variable period of cellular or tumor mass dormancy …

Initially described as lytic bodies due to their degradative and recycling functions, lysosomes
play a critical role in metabolic adaptation to nutrient availability. More recently, the …

The current focus in oncology research is the translational control of cancer cells as a major
mechanism of cellular plasticity. Recent evidence has prompted a reevaluation of the role of …

Dormant, disseminated breast cancer cells resist treatment and may relapse into malignant
metastases after decades of quiescence. Identifying how and why these dormant breast …

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders of the
gastrointestinal tract, mainly including Crohn's disease and ulcerative colitis …

Background Erythropoietin-producing hepatocellular (EPH) receptors are the largest known
family of receptor tyrosine kinases characterized in humans. These proteins are involved in …

Much of the fatality of tumors is linked to the growth of metastases, which can emerge
months to years after apparently successful treatment of primary tumors. Metastases arise …

Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being
implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor …

Objective To explore the involvement of TFEB-mediated autophagy-lysosomal mechanisms
in multiple myeloma (MM) during bortezomib treatment. Methods MM cells were exposed to …

EphB6 is an understudied ephrin receptor tyrosine pseudokinase that is downregulated in
multiple types of metastatic cancers. Unlike its kinase-active counterparts which …