A strong connection exists between the cell cycle and mechanisms required for executing
cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is …

Post-translation modifications of histones modulate the accessibility and transcriptional
competence of specific chromatin regions within the eukaryotic genome. Phosphorylation of …

The roles of post-translational histone modifications in regulating transcription and DNA
damage have been widely studied and discussed. Although mitotic histone marks …

Mitosis is accompanied by dramatic changes in chromatin organization and nuclear
architecture. Transcription halts globally and most sequence-specific transcription factors …

Regulation of transcription, replication, and cell division relies on differential protein binding
to DNA and chromatin, yet it is unclear which regulatory components remain bound to …

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To detect targeted antileukemia agents we have designed a novel, high-content in vivo
screen using genetically engineered, T-cell reporting zebrafish. We exploited the …

Histone H3 serine 10 phosphorylation is a hallmark of mitotic chromosomes, but its full
function remains to be elucidated. We report here that two SR protein splicing factors …

Epigenetic regulation of gene expression provides a finely tuned response capacity for cells
when undergoing environmental changes. However, in the context of human physiology or …

The changes imposed on the nucleus, chromatin and its regulators during mitosis lead to the
dismantlement of most gene regulatory processes. However, an increasing number of …