Abstract In 1956, Riker Laboratories, Inc.,(now 3 M Drug Delivery Systems) introduced the
first pressurized metered dose inhaler (MDI). In many respects, the introduction of the MDI …

The atomic force microscope (AFM) is not only a tool to image the topography of solid
surfaces at high resolution. It can also be used to measure force-versus-distance curves …

A wide range of dry powder inhaler (DPI) devices are currently available on the market to
deliver drugs into lungs with a view to maximise drug delivery with low variability. DPIs also …

The delivery efficiency of dry-powder products for inhalation is dependent upon the drug
formulation, the inhaler device, and the inhalation technique. Dry powder formulations are …

Pulmonary drug delivery is the focus of much research and development because of its
great potential to produce maximum therapeutic benefit. Among the available options the dry …

The inclusion of a small amount of fine particle excipient in a carrier-based dry powder
inhalation system is a well researched technique to improve formulation performance and is …

The motivation for this study was to find an adequate substitute for lactose as carrier in dry
powder inhalers and to overcome some drawbacks inherent to lactose. Mannitol appears to …

The performance of dry powder aerosols for the delivery of drugs to the lungs has been
studied extensively in the last decade. The focus for different research groups has been on …

The phenomenon of particle interaction involved in pulmonary drug delivery belongs to a
wide variety of disciplines of particle technology, in particular, fluidization. This paper …

Purpose To investigate the role of in situ generated fine excipient particles on the fluidization
and aerosolization properties of dry powder inhaler (DPI) formulations. Materials and …