Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups
L Anhäuser, F Muttach, A Rentmeister - Chemical Communications, 2018 - pubs.rsc.org
Methyltransferases are powerful tools for site-specific transfer of non-natural functional
groups from synthetic analogs of their cosubstrate S-adenosyl-L-methionine (AdoMet). We …
groups from synthetic analogs of their cosubstrate S-adenosyl-L-methionine (AdoMet). We …
Circular siRNAs for reducing off-target effects and enhancing long-term gene silencing in cells and mice
L Zhang, D Liang, C Chen, Y Wang, G Amu… - … Therapy-Nucleic Acids, 2018 - cell.com
Circular non-coding RNAs are found to play important roles in biology but are still relatively
unexplored as a structural motif for chemically regulating gene function. Here, we …
unexplored as a structural motif for chemically regulating gene function. Here, we …
Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation
In a previous study, we evaluated a HER2-specific single domain antibody fragment (sdAb)
2Rs15d labeled with 18 F via conjugation of a residualizing prosthetic agent that was …
2Rs15d labeled with 18 F via conjugation of a residualizing prosthetic agent that was …
Chemical synthesis of long RNAs with terminal 5′‐phosphate groups
Long structured RNAs are useful biochemical and biological tools. They are usually
prepared enzymatically, but this precludes their site‐specific modification with functional …
prepared enzymatically, but this precludes their site‐specific modification with functional …
Studies on Aculeines: Synthetic Strategy to the Fully Protected Protoaculeine B, the N-Terminal Amino Acid of Aculeine B
H Shiozaki, M Miyahara, K Otsuka, K Miyako… - Organic …, 2018 - ACS Publications
A synthetic strategy for accessing protoaculeine B (1), the N-terminal amino acid of the
highly modified peptide toxin aculeine, was developed via the synthesis of the fully protected …
highly modified peptide toxin aculeine, was developed via the synthesis of the fully protected …
Caged siRNAs with single folic acid modification of antisense RNA for photomodulation of exogenous and endogenous gene expression in cells
L Yu, N Jing, Z Yang, L Zhang, X Tang - Organic & Biomolecular …, 2018 - pubs.rsc.org
Manually controlling siRNA activity is an essentially important way to spatiotemporally
investigate gene expression and function. Owing to ease of operation and precise …
investigate gene expression and function. Owing to ease of operation and precise …
Wavelength-selective light-triggered strand exchange reaction
K Morihiro, T Kodama, S Mori, S Tsunoda… - Organic & Biomolecular …, 2016 - pubs.rsc.org
We prepared an oligodeoxynucleotide (ODN) bearing two 4-hydroxy-2-
mercaptobenzimidazole nucleobase analogues (SBNV and SBNB) modified with different …
mercaptobenzimidazole nucleobase analogues (SBNV and SBNB) modified with different …
Release of Terminal Alkynes via Tandem Photodeprotection and Decarboxylation of o-Nitrobenzyl Arylpropiolates in a Flow Microchannel Reactor
Photocleavable protecting groups (PPGs) offer a complementary protection paradigm
compared to traditional protection groups. Herein, an o-nitrobenzyl (NB) PPG was employed …
compared to traditional protection groups. Herein, an o-nitrobenzyl (NB) PPG was employed …
Synthesis and enzymatic incorporation of photolabile dUTP analogues into DNA and their applications for DNA labeling
J Wu, X Tang - Bioorganic & medicinal chemistry, 2013 - Elsevier
Two novel photolabile nucleotide triphosphate (NTP) analogues were synthesized through
Sonogashira coupling and their enzymatic incorporation into DNA was evaluated with three …
Sonogashira coupling and their enzymatic incorporation into DNA was evaluated with three …
Photoremovable NPEC group compatible with Ns protecting group in polyamine synthesis
M Miyahara, H Shiozaki, H Tukada, Y Ishikawa… - Tetrahedron …, 2018 - Elsevier
Herein, we disclose an efficient combination of NPEC and Ns protecting groups in the
synthesis of polyamine, by showing the orthogonal reactivity using N-NPEC-N-Ns …
synthesis of polyamine, by showing the orthogonal reactivity using N-NPEC-N-Ns …