Homology modeling is a method for building protein 3D structures using protein primary
sequence and utilizing prior knowledge gained from structural similarities with other …

Stringent factors orchestrate bacterial cell reprogramming through increasing the level of the
alarmones (p) ppGpp. In Beta-and Gammaproteobacteria, SpoT hydrolyzes (p) ppGpp to …

In budding yeast, the MutL homolog heterodimer Mlh1-Mlh3 (MutLγ) plays a central role in
the formation of meiotic crossovers. It is also involved in the repair of a subset of mismatches …

Abstract Laminarin, a β (1, 3)‐glucan, serves as a storage polysaccharide in marine
microalgae such as diatoms. Its abundance, water solubility and simple structure make it an …

The molecular mechanisms and forces involved in the translocation of bacterial toxins into
host cells are still a matter of intense research. The adenylate cyclase (CyaA) toxin from …

Replicative helicases are essential proteins that unwind DNA in front of replication forks.
Their loading depends on accessory proteins and in bacteria, DnaC and DnaI are well …

Objective The liver-derived circulating PCSK9 enhances the degradation of the LDL
receptor (LDLR) in endosomes/lysosomes. PCSK9 inhibition or silencing is presently used …

Abstract JIP3 and JIP4 (JNK-interacting proteins 3 and 4) are adaptors for cargo recruitment
by dynein/dynactin and kinesin1 motors. Both are dimers that are stabilised by two sections …

Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone
deposition with DNA synthesis. This process relies on the evolutionary conserved histone …

While X-ray crystallography remains the most popular and productive technique for protein
structure determination, it very often produces incomplete models, either due to truncations …