[HTML][HTML] The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

KE De Visser, JA Joyce - Cancer cell, 2023 - cell.com
Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Cancer neuroscience: State of the field, emerging directions

F Winkler, HS Venkatesh, M Amit, T Batchelor, IE Demir… - Cell, 2023 - cell.com
The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

The updated landscape of tumor microenvironment and drug repurposing

MZ Jin, WL Jin - Signal transduction and targeted therapy, 2020 - nature.com
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Tumor microenvironment in glioblastoma: Current and emerging concepts

P Sharma, A Aaroe, J Liang… - Neuro-Oncology …, 2023 - academic.oup.com
Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …

Olfactory sensory experience regulates gliomagenesis via neuronal IGF1

P Chen, W Wang, R Liu, J Lyu, L Zhang, B Li, B Qiu… - Nature, 2022 - nature.com
Animals constantly receive various sensory stimuli, such as odours, sounds, light and touch,
from the surrounding environment. These sensory inputs are essential for animals to search …

[HTML][HTML] Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy

XP Xie, DR Laks, D Sun, M Ganbold, Z Wang… - Developmental cell, 2022 - cell.com
We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-
proliferative therapies. Functional characterization of spontaneous glioblastomas from …

NF1 mutation drives neuronal activity-dependent initiation of optic glioma

Y Pan, JD Hysinger, T Barron, NF Schindler, O Cobb… - Nature, 2021 - nature.com
Neurons have recently emerged as essential cellular constituents of the tumour
microenvironment, and their activity has been shown to increase the growth of a diverse …

Disconnecting multicellular networks in brain tumours

V Venkataramani, M Schneider, FA Giordano… - Nature Reviews …, 2022 - nature.com
Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

Cancer-associated neurogenesis and nerve-cancer cross-talk

DA Silverman, VK Martinez, PM Dougherty, JN Myers… - Cancer research, 2021 - AACR
In this review, we highlight recent discoveries regarding mechanisms contributing to nerve-
cancer cross-talk and the effects of nerve-cancer cross-talk on tumor progression and …

[HTML][HTML] Bioelectronic medicine: preclinical insights and clinical advances

VA Pavlov, KJ Tracey - Neuron, 2022 - cell.com
The nervous system maintains homeostasis and health. Homeostatic disruptions underlying
the pathobiology of many diseases can be controlled by bioelectronic devices targeting CNS …