Fungal endophytes as efficient sources of plant-derived bioactive compounds and their prospective applications in natural product drug discovery: Insights, avenues …

A Singh, DK Singh, RN Kharwar, JF White, SK Gond - Microorganisms, 2021 - mdpi.com
Fungal endophytes are well-established sources of biologically active natural compounds
with many producing pharmacologically valuable specific plant-derived products. This …

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (Artemisia absinthium)

GES Batiha, A Olatunde, A El-Mleeh, HF Hetta… - Antibiotics, 2020 - mdpi.com
Plants have been used since ancient times to cure certain infectious diseases, and some of
them are now standard treatments for several diseases. Due to the side effects and …

The molecular mechanism of action of artemisinin—the debate continues

PM O'Neill, VE Barton, SA Ward - Molecules, 2010 - mdpi.com
Despite international efforts to 'roll back malaria'the 2008 World Malaria Report revealed the
disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …

Discovery, mechanisms of action and combination therapy of artemisinin

L Cui, X Su - Expert review of anti-infective therapy, 2009 - Taylor & Francis
Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

[HTML][HTML] Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

AM Posadino, R Giordo, G Pintus… - Biomedicine & …, 2023 - Elsevier
Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has
been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial …

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

F Rocamora, L Zhu, KY Liong, A Dondorp… - PLoS …, 2018 - journals.plos.org
Due to their remarkable parasitocidal activity, artemisinins represent the key components of
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …

[HTML][HTML] Artemisinins: their growing importance in medicine

S Krishna, L Bustamante, RK Haynes… - Trends in pharmacological …, 2008 - cell.com
Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well
established for the treatment of malaria, including highly drug-resistant strains. Their efficacy …

Antimalarial drug resistance and implications for the WHO global technical strategy

MM Ippolito, KA Moser, JBB Kabuya… - Current epidemiology …, 2021 - Springer
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …

Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than …

M Sehailia, S Chemat - Journal of Biomolecular Structure and …, 2021 - Taylor & Francis
Medicinal herbs have proved along history to be a source of multiple cures. In this paper, we
demonstrate how hydroxychloroquine can act as a good inhibitor of SARS-CoV-2 Spike …

Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development

M Schlitzer - ChemMedChem: Chemistry Enabling Drug …, 2007 - Wiley Online Library
Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …