ABC transporters fulfill diverse physiological functions in different cellular localizations
ranging from the plasma membrane to intracellular membranous compartments. Several …

Cancer is one of the leading causes of mortality in the developed countries. The search for
novel drug candidates is a priority goal for cancer therapy. However, the emergence of drug …

Background: Docetaxel is the only FDA-approved first-line treatment for castration-resistant
prostate cancer (CRPC) patients. Docetaxel treatment inevitably leads to tumour recurrence …

Biomarkers are biological molecules found in body fluids or tissues, which can be
considered as indications of a normal or abnormal process, or of a condition or disease …

Transcription factor EB (TFEB), a member of the MiT family, is dysregulated in different
cancers and exerts specific biological functions within the tumor microenvironment …

Introduction Gangliosides play an essential role in cancer development and progression.
However, the involvement of gangliosides in the prognosis and tumor microenvironment …

Purpose The aim of this work was to study the correlation between the expressions of the
ABCA2 and ABCA3 genes at the mRNA and protein levels in children with acute …

Pediatric acute lymphoblastic leukemia (pALL) includes 75% of childhood leukemias, and
methotrexate (MTX) is one of the most effective chemotherapy agents prescribed for pALL …

ATP-binding cassette (ABC) transporters are membrane-bound proteins that actively
translocate endo-and xenobiotic solutes across cellular membranes at the expense of …

Docetaxel has been the standard first-line therapy in metastatic castration resistant prostate
cancer. The survival benefit is, however, limited by either primary or acquired resistance. In …