Polyploidy has been described in the liver for over 100 years. The frequency of polyploid
hepatocytes varies by age and species, but up to 90% of mouse hepatocytes and …

A balanced increase in DNA content (ploidy) is observed in some human cell types,
including bone-resorbing osteoclasts, platelet-producing megakaryocytes, cardiomyocytes …

Polyploidization is one of the most dramatic changes that can occur in the genome. In the
liver, physiological polyploidization events occur during both liver development and …

Increased iron stores associated with elevated levels of the iron hormone hepcidin are a
frequent feature of the metabolic syndrome. The aim of this study was to assess the effect of …

Iron (Fe) is an essential element that plays a fundamental role in a wide range of cellular
functions, including cellular proliferation, DNA synthesis, as well as DNA damage and …

The liver is the main storage site for iron in the body. Excess accumulation of iron in the liver
has been well-documented in two human diseases, hereditary hemochromatosis and …

Aurora kinases belong to a conserved family of serine/threonine kinases key regulators of
cell cycle progression. Aurora-A and Aurora-B are expressed in somatic cells and involved …

Background Myricitrin has been reported to exert protective effects on liver diseases, but the
protective effects of myricitrin against liver ischemia reperfusion (I/R) injury and the …

Background Iron is an essential element for growth and metabolic activities of all living
organisms but remains in its oxyhydroxide ferric ion form in the surrounding. Unavailability of …

During the inflammatory process, hepcidin overexpression favours the development of
anaemia of chronic diseases which represents the second most common form of anaemia …