Skin wound repair is a multistage process involving multiple cellular and molecular
interactions, which modulate the cell behaviors and dynamic remodeling of extracellular …

Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

The process of wound healing involves a complex and vast interplay of growth factors and
cytokines that coordinate the recruitment and interaction of various cell types. A series of …

Chronic wounds affect healthcare systems and increase the risk of infection. Despite the
clinical demand for improving healing, an effective and safe therapeutic approach is still …

Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …

Small intestinal submucosa (SIS) hydrogel is a potential candidate for wound dressing since
its excellent biocompatibility and bioactivities. However, the intrinsic lack of sufficient …

Fibrosis is a pathophysiological process of wound repair that leads to the deposit of
connective tissue in the extracellular matrix. This complication is mainly associated with …

Wound healing is a physiological process, involving three successive and overlapping
phases—hemostasis/inflammation, proliferation, and remodeling—to maintain the integrity …

A large number of cytokines or growth factors have been used in the treatment of
inflammation. However, they are highly dependent on an optimal delivery system with …

Abstract Rationale: The Notch and transforming growth factor-β (TGFβ) signaling pathways
are two intracellular mechanisms that control fibrosis in general but whether they play a …