Various non-nucleic acid targets (ions, small molecules, polysaccharides, peptides/proteins/
enzymes, cells, transcription factors) are important biomarkers. They play important roles in …

CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-
associated) proteins are powerful gene-editing tools because of their ability to accurately …

Pathogenic bacteria infection severely threatens human health and causes substantial
medical and financial concern. Rapid, sensitive, specific, and reliable detection of …

Highlights•We develop a versatile biosensing platform for ultrasensitive detection of
pathogenic bacteria, termed as SCENT-Cas.•SCENT-Cas adopts ratiometric fluorescence …

The pandemic of coronavirus disease 2019 (COVID-19) resulted from novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide concern. It is …

The continuing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infection, which causes coronavirus disease 2019 (COVID-19), has spread globally and …

Since their discovery, CRISPR/Cas systems have been extensively exploited in nucleic acid
biosensing. However, the vast majority of contemporary platforms offer only qualitative …

Herein, a chemiluminescence (CL) biosensor based on CRISPR-Cas12a and cation
exchange reaction was constructed to detect the biomarker microRNA-21 (miRNA-21). The …

In this study, a CRISPR/Cas12a (LbCpf1)-mediated electrochemiluminescence (ECL) paper-
based platform on the basis of a three-dimensional (3D) DNA walker was proposed for the …

Timely diagnosis is of great benefit to improve the survival rate of cancer patients. Body fluid
cancer biomarker detection is a critical kind of noninvasive method for cancer diagnosis …