Genetics, genomics, and diet interactions in obesity in the Latin American environment

P Guevara-Ramírez, S Cadena-Ullauri… - Frontiers in …, 2022 - frontiersin.org
Obesity is a chronic disease characterized by abnormal or excessive fat accumulation that
could impact an individual's health; moreover, the World Health Organization (WHO) has …

Role of liver parameters in diabetes mellitus–a narrative review

S Rafaqat, A Sattar, A Khalid, S Rafaqat - Endocrine Regulations, 2023 - sciendo.com
Diabetes mellitus is characterized by hyperglycemia and abnormalities in insulin secretion
and function. This review article focuses on various liver parameters, including albumin …

Multi-ancestry polygenic mechanisms of type 2 diabetes

K Smith, AJ Deutsch, C McGrail, H Kim, S Hsu… - Nature medicine, 2024 - nature.com
Abstract Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for
which the underlying biological mechanisms are not fully understood. In this study, we …

Association of Low Serum Bilirubin Concentrations and Promoter Variations in the UGT1A1 and HMOX1 Genes with Type 2 Diabetes Mellitus in the Czech …

A Jirásková, J Škrha, L Vítek - International Journal of Molecular Sciences, 2023 - mdpi.com
Bilirubin has potent biological beneficial effects, protecting against atherosclerosis, obesity,
and metabolic syndrome. The aim of this study was to assess serum bilirubin concentrations …

Identification of the risk factors of type 2 diabetes and its prediction using machine learning techniques

MM Islam, MJ Rahman, M Menhazul Abedin… - Health …, 2023 - Taylor & Francis
This study identified the risk factors for type 2 diabetes (T2D) and proposed a machine
learning (ML) technique for predicting T2D. The risk factors for T2D were identified by …

[HTML][HTML] Toward nanotechnology-enabled application of bilirubin in the treatment and diagnosis of various civilization diseases

Y Cui, C Wu, L Li, CY Li, S Yin - Materials Today Bio, 2023 - Elsevier
Bilirubin, an open chain tetrapyrrole, has powerful antioxidant, anti-inflammatory, immuno-
suppressive, metabolic-modulating and anti-proliferative activities. Bilirubin is a natural …

[HTML][HTML] The J-shape Association between Total Bilirubin and Stroke in Older Patients with Obstructive Sleep Apnea Syndrome: A Multicenter Study

Y Gao, L Zhao, K Li, X Su, X Li, J Li, Z Zhao… - The Journal of nutrition …, 2023 - Elsevier
Objectives To explore the relationship between total bilirubin (TBil) and stroke risk in older
patients with obstructive sleep apnea syndrome (OSAS). Methods A total of 1,007 patients …

Positive association between serum bilirubin within the physiological range and serum testosterone levels

C Ling, Y Liu, M Yao, L Tian - BMC Endocrine Disorders, 2024 - Springer
Backgrounds Research has demonstrated that elevated serum total bilirubin (STB) levels
have a beneficial impact on various diseases, particularly metabolic syndrome. This study …

[HTML][HTML] Multi-ancestry polygenic mechanisms of type 2 diabetes elucidate disease processes and clinical heterogeneity

K Smith, AJ Deutsch, C McGrail, H Kim, S Hsu… - medRxiv, 2023 - ncbi.nlm.nih.gov
We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from
diverse groups, including non-European populations. We implemented soft clustering with …

Efficient biosynthesis of bilirubin by overexpressing heme oxygenase, biliverdin reductase and 5-aminolevulinic acid dehydratase in Escherichia coli

Z Liu, P Xiong, N Guo, H Chen - Molecular Catalysis, 2025 - Elsevier
Bilirubin IXα (BR) offers health benefits in cardiovascular health, stroke, diabetes and
metabolic syndrome. BR is mainly extracted from pig bile, bringing potential risks due to …