[HTML][HTML] Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics
Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …
Current and prospective computational approaches and challenges for developing COVID-19 vaccines
Abstract SARS-CoV-2, which causes COVID-19, was first identified in humans in late 2019
and is a coronavirus which is zoonotic in origin. As it spread around the world there has …
and is a coronavirus which is zoonotic in origin. As it spread around the world there has …
Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations
TN Johnson, BG Small… - CPT: Pharmacometrics & …, 2022 - Wiley Online Library
There has been a significant increase in the use of physiologically based pharmacokinetic
(PBPK) models during the past 20 years, especially for pediatrics. The aim of this study was …
(PBPK) models during the past 20 years, especially for pediatrics. The aim of this study was …
Characterizing pharmacokinetics in children with obesity—physiological, drug, patient, and methodological considerations
Childhood obesity is an alarming public health problem. The pediatric obesity rate has
quadrupled in the past 30 years, and currently nearly 20% of United States children and 9 …
quadrupled in the past 30 years, and currently nearly 20% of United States children and 9 …
Emerging trends and therapeutic applications of monoclonal antibodies
Monoclonal antibodies (mAbs) are being used to prevent, detect, and treat a broad spectrum
of malignancies and infectious and autoimmune diseases. Over the past few years, the …
of malignancies and infectious and autoimmune diseases. Over the past few years, the …
Age-related changes in pediatric physiology: quantitative analysis of organ weights and blood flows: age-related changes in pediatric physiology
Abstract Development of comprehensive and updated quantitative relationships between
physiological parameters and age for pediatrics remains to be accomplished. Towards this …
physiological parameters and age for pediatrics remains to be accomplished. Towards this …
Revisiting the in-vitro and in-vivo considerations for in-silico modelling of complex injectable drug products
Complex injectable drug products (CIDPs) have often been developed to modulate the
pharmacokinetics along with efficacy for therapeutic agents used for remediation of chronic …
pharmacokinetics along with efficacy for therapeutic agents used for remediation of chronic …
Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits
Physiologically based pharmacokinetic (PBPK) modelling is an important tool to predict drug
disposition in the body. Rabbits play a pivotal role as a highly valued small animal model …
disposition in the body. Rabbits play a pivotal role as a highly valued small animal model …
Opportunities and challenges for PBPK model of mAbs in paediatrics and pregnancy
KL Gill, HM Jones - The AAPS Journal, 2022 - Springer
New drugs may in some cases need to be tested in paediatric and pregnant patients.
However, it is difficult to recruit such patients and there are many ethical issues around their …
However, it is difficult to recruit such patients and there are many ethical issues around their …
Opportunities for systems biology and quantitative systems pharmacology to address Knowledge gaps for drug development in pregnancy
JS Barrett, K Azer - The Journal of Clinical Pharmacology, 2023 - Wiley Online Library
Pregnant women are still viewed as therapeutic orphans to the extent that they are avoided
as participants in mainstream clinical trials and not considered a priority for targeted drug …
as participants in mainstream clinical trials and not considered a priority for targeted drug …