B cells are key components of the adaptive immune response. Their differentiation into
either specific memory B cells or antibody-secreting plasma cells is a consequence of …

T cell activation depends on extracellular ligation of the T cell receptor (TCR) by peptide–
MHC complexes in a synapse between the T cell and an antigen-presenting cell. The …

A key role is emerging for the cytoskeleton in coordinating receptor signaling, although the
underlying molecular requirements remain unclear. Here we show that cytoskeleton …

Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion
signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The …

The actin cytoskeleton is essential for cell mechanics and has increasingly been implicated
in the regulation of cell signalling. In B cells, the actin cytoskeleton is extensively coupled to …

Signaling through the B cell receptor (BCR) plays a critical role at multiple checkpoints of B
cell biology. BCR acts as a gatekeeper of the progression of their early development in bone …

T cells constitute a crucial arm of the adaptive immune system and their optimal function is
required for a healthy immune response. After the initial step of T cell-receptor (TCR) …

Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This
may be of particular importance in the context of immune receptors, such as the B cell …

It is well known that F-actin dynamics drive the micron-scale cell shape changes required for
migration and immunological synapse (IS) formation. In addition, recent evidence points to a …

Engineered nano–bio cellular interfaces driven by 1D vertical nanostructures (1D‐VNS) are
set to prompt radical progress in modulating cellular processes at the nanoscale. Here …