Microbiota and epigenetics: promising therapeutic approaches?

A El-Sayed, L Aleya, M Kamel - Environmental Science and Pollution …, 2021 - Springer
The direct/indirect responsibility of the gut microbiome in disease induction in and outside
the digestive tract is well studied. These results are usually from the overpopulation of …

Epigenetics and the role of nutraceuticals in health and disease

A El-Sayed, L Aleya, M Kamel - Environmental Science and Pollution …, 2023 - Springer
In the post-genomic era, the data provided by complete genome sequencing could not
answer several fundamental questions about the causes of many noninfectious diseases …

Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory mediators in rats

MMM Elbakry, SZ Mansour, H Helal… - … Science and Pollution …, 2022 - Springer
Nattokinase (NK), a protease enzyme produced by Bacillus subtilis, has various biological
effects such as lipid-lowering activity, antihypertensive, antiplatelet/anticoagulant, and …

Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: co-operative role of ER-β, TGF-β, and FOXL-2

YH Haddad, RS Said, R Kamel, EME Morsy… - Scientific Reports, 2020 - nature.com
Radiotherapy is a well-known cause of premature ovarian failure (POF). Therefore, we
investigated the molecular influence of genistein (GEN) on the ovarian reserve of rats …

Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome

MR Landauer, AJ Harvey, MD Kaytor… - Journal of radiation …, 2019 - academic.oup.com
There are no FDA-approved drugs that can be administered prior to ionizing radiation
exposure to prevent hematopoietic–acute radiation syndrome (H-ARS). A suspension of …

A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice

VK Singh, OO Fatanmi, SY Wise… - … journal of radiation …, 2022 - Taylor & Francis
Purpose Exposure to high doses of ionizing radiation can result in hematopoietic acute
radiation syndrome (H-ARS) and delayed effects of acute radiation exposure (DEARE) …

Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure

M Girgis, Y Li, J Ma, M Sanda, SY Wise, OO Fatanmi… - Scientific Reports, 2020 - nature.com
Hematopoietic acute radiation syndrome (H-ARS) and delayed effects of acute radiation
exposure (DEARE) are detrimental health effects that occur after exposure to high doses of …

Serum melatonin is inversely associated with matrix metalloproteinase-9 in oral squamous cell carcinoma

AE Stanciu, A Zamfir-Chiru-Anton… - Oncology …, 2020 - spandidos-publications.com
Matrix-metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) expression levels have
been demonstrated to have prognostic value in oral squamous cell carcinoma (OSCC). The …

Genistein From Fructus sophorae Protects Mice From Radiation-Induced Intestinal Injury

J Zhang, Z Pang, Y Zhang, J Liu, Z Wang… - Frontiers in …, 2021 - frontiersin.org
The development of an effective pharmacological countermeasure is needed to reduce the
morbidity and mortality in high-dose ionizing radiation-induced acute damage. Genistein …

Melatonin in chemo/radiation therapy; implications for normal tissues sparing and tumor suppression: an updated review

J Gupta, AF Almulla, AT Jalil, NY Jasim… - Current Medicinal …, 2025 - benthamdirect.com
Resistance to therapy and the toxicity of normal tissue are the major problems for efficacy
associated with chemotherapy and radiotherapy. Drug resistance is responsible for most …