The role of chromatin loop extrusion in antibody diversification
Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …
between convergently oriented CTCF-binding elements. Recent studies indicate that …
RAG chromatin scanning during V (D) J recombination and chromatin loop extrusion are related processes
An effective adaptive immune system depends on the ability of developing B and T cells to
generate diverse immunoglobulin (Ig) and T cell receptor repertoires, respectively. Such …
generate diverse immunoglobulin (Ig) and T cell receptor repertoires, respectively. Such …
Loop extrusion mediates physiological Igh locus contraction for RAG scanning
RAG endonuclease initiates Igh V (D) J recombination in progenitor B cells by binding a JH-
recombination signal sequence (RSS) within a recombination centre (RC) and then linearly …
recombination signal sequence (RSS) within a recombination centre (RC) and then linearly …
A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters
W Wang, S Qiao, G Li, J Cheng, C Yang… - Nucleic acids …, 2022 - academic.oup.com
As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter
connection. However, gaps still exist in understanding how YY1 coordinates coactivators …
connection. However, gaps still exist in understanding how YY1 coordinates coactivators …
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens
EM Barajas-Mora, L Lee, H Lu, JA Valderrama… - Nature …, 2023 - nature.com
Antigen receptor loci are organized into variable (V), diversity (D) and joining (J) gene
segments that rearrange to generate antigen receptor repertoires. Here, we identified an …
segments that rearrange to generate antigen receptor repertoires. Here, we identified an …
An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation
The mouse Igh locus is organized into a developmentally regulated topologically associated
domain (TAD) that is divided into subTADs. Here we identify a series of distal VH enhancers …
domain (TAD) that is divided into subTADs. Here we identify a series of distal VH enhancers …
Spatial organization of chromatin: Transcriptional control of adaptive immune cell development
JMR Pongubala, C Murre - Frontiers in immunology, 2021 - frontiersin.org
Higher-order spatial organization of the genome into chromatin compartments (permissive
and repressive), self-associating domains (TADs), and regulatory loops provides structural …
and repressive), self-associating domains (TADs), and regulatory loops provides structural …
A lamina-associated domain border governs nuclear lamina interactions, transcription, and recombination of the Tcrb locus
Summary Tcrb locus V (D) J recombination is regulated by positioning at the nuclear
periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at …
periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at …
Contribution of immunoglobulin enhancers to B cell nuclear organization
C Bruzeau, J Cook-Moreau, E Pinaud… - Frontiers in …, 2022 - frontiersin.org
B cells undergo genetic rearrangements at immunoglobulin gene (Ig) loci during B cell
maturation. First V (D) J recombination occurs during early B cell stages followed by class …
maturation. First V (D) J recombination occurs during early B cell stages followed by class …
[HTML][HTML] Many facades of CTCF unified by its coding for three-dimensional genome architecture
Q Wu, P Liu, L Wang - Journal of Genetics and Genomics, 2020 - Elsevier
CCCTC-binding factor (CTCF) is a multifunctional zinc-finger protein that is conserved in
metazoan species. CTCF is consistently found to play an important role in many diverse …
metazoan species. CTCF is consistently found to play an important role in many diverse …