Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …

Astrocytes undergo an inflammatory transition after infections, acute injuries and chronic
neurodegenerative diseases. How this transition is affected by time and sex, its …

Magnesium is an essential element of life, involved in the regulation of metabolism and
homeostasis of all the tissues. It also regulates immunological functions, acting on the cells …

The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic
organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from …

Overcoming resistance to chemotherapies remains a major unmet need for cancers, such as
triple-negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for …

The inception of cancer treatment with chemotherapeutics began in the 1940s with nitrogen
mustards that were initially employed as weapons in World War II. Since then, treatment …

Viruses hijack host metabolic pathways for their replicative advantage. In this study, using
patient-derived multiomics data and in vitro infection assays, we aimed to understand the …

Macrophages are versatile immune cells associated with various diseases, and their
phenotypes and functions change on the basis of the surrounding environments …

Glutamate, as one of the most important carbon sources in the TCA cycle, is central in
metabolic processes that will subsequently influence tumor progression. Several factors can …