After the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …

Implantable devices capable of targeted and reversible blocking of peripheral nerve activity
may provide alternatives to opioids for treating pain. Local cooling represents an attractive …

In the most influential monograph on colloid and interfacial science by Adamson three
fundamental equations of “physical chemistry of surfaces” are identified: the Laplace …

Perfluorocarbon nanodroplets (PFCnDs) are sub-micrometer emulsions composed of a
surfactant-encased perfluorocarbon (PFC) liquid and can be formulated to transiently …

Phase-change contrast agents are rapidly developing as an alternative to microbubbles for
ultrasound imaging and therapy. These agents are synthesized and delivered as liquid …

A new contrast agent for combined photoacoustic and ultrasound imaging is presented. It
has a liquid perfluorocarbon (PFC) core of about 250 nm diameter coated by a 30 nm thin …

We demonstrate a versatile phase-change sub-micron contrast agent providing three modes
of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with …

Technologies enabling in vivo range verification during proton therapy are actively sought
as a means to reduce the clinical safety margins currently adopted to avoid tumor …

Phase-shift droplets are a highly adaptable platform for biomedical applications of
ultrasound. The spatiotemporal response of phase-shift droplets to focused ultrasound …

Phase-change perfluorocarbon microdroplets were introduced over 2 decades ago to
occlude downstream vessels in vivo. Interest in perfluorocarbon nanodroplets has recently …