Viral infections and male infertility: a comprehensive review of the role of oxidative stress

RE Akhigbe, S Dutta, MA Hamed, AF Ajayi… - … in Reproductive Health, 2022 - frontiersin.org
Viral infections have been a part of human existence to date, though viruses have posed a
huge threat with various outbreaks lately. These threats are associated with reproductive …

Impact of stress on male fertility: role of gonadotropin inhibitory hormone

AF Odetayo, RE Akhigbe, GE Bassey… - Frontiers in …, 2024 - frontiersin.org
Studies have implicated oxidative stress-sensitive signaling in the pathogenesis of stress-
induced male infertility. However, apart from oxidative stress, gonadotropin inhibitory …

[HTML][HTML] Glutamine prevents upregulation of NF-kB signaling and caspase 3 activation in ischaemia/reperfusion-induced testicular damage: An animal model

OA Afolabi, DC Anyogu, MA Hamed, AF Odetayo… - Biomedicine & …, 2022 - Elsevier
Aim Testicular ischaemia/reperfusion (I/R) injury is a major consequence of testicular torsion
with possible attendant risk of male infertility. Glutamine, on the other hand, is a known …

Zinc improves sexual and erectile function in HAART-treated rats via the upregulation of erectogenic enzymes and maintenance of redox balance

RE Akhigbe, MA Hamed, AF Odetayo, TM Akhigbe… - The Aging …, 2023 - Taylor & Francis
Purpose HAART has been shown to impair sexual function and penile erection via
perturbation of penile redox balance, while zinc has been established to exert antioxidant …

[HTML][HTML] Omega-3 fatty acid rescues ischaemia/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine oxidase/uric acid …

RE Akhigbe, MA Hamed, AF Odetayo… - Biomedicine & …, 2021 - Elsevier
This study aimed to explore the potential antioxidant, anti-inflammatory, and anti-apoptotic
effects of omega 3 fatty acid (Ω-3) in a rat model of testicular torsion/detorsion (T/D). Under …

[HTML][HTML] Glutamine restores testicular glutathione-dependent antioxidant defense and upregulates NO/cGMP signaling in sleep deprivation-induced reproductive …

MA Hamed, TM Akhigbe, RE Akhigbe… - Biomedicine & …, 2022 - Elsevier
Oxidative stress has been linked with sleep deprivation (SD)-induced pathological
conditions and reproductive dysfunction. On the other hand, glutamine has been established …

Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats

EE Besong, TM Akhigbe, PJ Ashonibare… - Redox …, 2023 - Taylor & Francis
Aim: The present study evaluated the effect of lead exposure with and without zinc therapy
on male sexual and erectile function. Methods: Twenty male Wistar rats were randomly …

[HTML][HTML] Suppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in …

WA Saka, RE Akhigbe, AO Abidoye, OS Dare… - Biomedicine & …, 2021 - Elsevier
Dichlorvos is a known risk factor for organ toxicity. The liver and kidney are essential
metabolic tissues but it is unclear whether or not there is associated redox dyshomeostasis …

Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats

MA Hamed, RE Akhigbe, AO Aremu… - Chemico-Biological …, 2022 - Elsevier
Background Although highly active antiretroviral therapy (HAART) is effective in the
management of HIV, it has been reported to induce hepatic injury and non-alcoholic fatty …

Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid–Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats

EE Besong, TM Akhigbe, JN Obimma… - … Trace Element Research, 2024 - Springer
Arsenic is associated with male reproductive toxicity through histone deacetylation and
oxido-inflammatory injury. Notwithstanding, short-chain fatty acids such as acetate exert anti …