Beneath the skin: a review of current trends and future prospects of transdermal drug delivery systems

AZ Alkilani, J Nasereddin, R Hamed, S Nimrawi… - Pharmaceutics, 2022 - mdpi.com
The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms
but is as convenient and easy to use for the patient as oral solid dosage forms. In recent …

Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum

A Zaid Alkilani, MTC McCrudden, RF Donnelly - Pharmaceutics, 2015 - mdpi.com
The skin offers an accessible and convenient site for the administration of medications. To
this end, the field of transdermal drug delivery, aimed at developing safe and efficacious …

[HTML][HTML] Enhancement of transdermal drug delivery via synergistic action of chemicals

P Karande, S Mitragotri - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
Transdermal drug delivery is an attractive alternative to conventional techniques for
administration of systemic therapeutics. One challenge in designing transdermal drug …

Spray freeze drying: Emerging applications in drug delivery

DA Vishali, J Monisha, SK Sivakamasundari… - Journal of Controlled …, 2019 - Elsevier
Spray freeze drying is relatively a recent drying technique involving heterogeneous set of
steps which includes droplet formation, freezing, and sublimation. It has proven benefits over …

Micro-scale devices for transdermal drug delivery

A Arora, MR Prausnitz, S Mitragotri - International journal of pharmaceutics, 2008 - Elsevier
Skin makes an excellent site for drug and vaccine delivery due to easy accessibility, immuno-
surveillance functions, avoidance of macromolecular degradation in the gastrointestinal tract …

Immunization without needles

S Mitragotri - Nature Reviews Immunology, 2005 - nature.com
Most current immunization procedures make use of needles and syringes for vaccine
administration. With the increase in the number of immunizations that children around the …

Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: Proof of concept

LK Vora, RF Donnelly, E Larrañeta… - Journal of Controlled …, 2017 - Elsevier
Polymeric microneedle (MN) arrays continue to receive growing attention due to their ability
to bypass the skin's stratum corneum barrier in a minimally-invasive fashion and achieve …

[HTML][HTML] High-velocity micro-projectile impact testing

D Veysset, JH Lee, M Hassani, SE Kooi… - Applied Physics …, 2021 - pubs.aip.org
High-velocity microparticle impacts are relevant to many fields, from space exploration to
additive manufacturing, and can be used to help understand the physical and chemical …

Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers

S Mitragotri - Advanced drug delivery reviews, 2013 - Elsevier
Overcoming biological barriers including skin, mucosal membranes, blood brain barrier as
well as cell and nuclear membrane constitutes a key hurdle in the field of drug delivery …

Physical non-viral gene delivery methods for tissue engineering

AJ Mellott, ML Forrest, MS Detamore - Annals of biomedical engineering, 2013 - Springer
The integration of gene therapy into tissue engineering to control differentiation and direct
tissue formation is not a new concept; however, successful delivery of nucleic acids into …