The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Rhoptries are specialized secretory organelles found in the Apicomplexa phylum, playing a
central role in the establishment of parasitism. The rhoptry content includes membranous as …

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is
caused by the intracellular parasite Plasmodium. However, increased resistance to ACT …

Spread of parasite resistance to artemisinin threatens current frontline antimalarial
therapies, highlighting the need for new drugs with alternative modes of action. Since only …

Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be
fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic …

Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress
and invasion of erythrocytes, development of functional liver merozoites (prophylactic …

Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium.
Their functions are strikingly multifaceted, ranging from hemoglobin degradation to secretory …

Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

Plasmodium spp. parasites that cause malaria disease remain a significant global-health
burden. With the spread of parasites resistant to artemisinin combination therapies in …

The pathology of malaria is caused by infection of red blood cells with unicellular
Plasmodium parasites. During blood-stage development, the parasite replicates within a …