Intratumour heterogeneity (ITH) is a hallmark of cancer that drives tumour evolution and
disease progression. Technological and computational advances have enabled us to …

SMARCA4, also known as transcription activator, is an ATP-dependent catalytic subunit of
SWI/SNF (SWItch/Sucrose NonFermentable) chromatin-remodeling complexes that …

Molecular modifiers of KRASG12C inhibitor (KRASG12Ci) efficacy in advanced KRAS G12C-
mutant NSCLC are poorly defined. In a large unbiased clinicogenomic analysis of 424 …

Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform …

Summary We analyzed 2,532 lung adenocarcinomas (LUAD) to identify the
clinicopathological and genomic features associated with metastasis, metastatic burden …

Immunosurveillance of cancer requires the presentation of peptide antigens on major
histocompatibility complex class I (MHC-I) molecules,,,–. Current approaches to profiling of …

Many cancers originate from stem or progenitor cells hijacked by somatic mutations that
drive replication, exemplified by adenomatous transformation of pulmonary alveolar …

Cancer cells are plastic–they can assume a wide range of distinct phenotypes. Plasticity is
integral to cancer initiation and progression, as well as to the emergence and maintenance …

Cancer of unknown primary (CUP) is a syndrome defined by clinical absence of a primary
cancer after standardised investigations. Gene expression profiling (GEP) and DNA …

Progressive tissue fibrosis, including idiopathic pulmonary fibrosis (IPF), is characterized by
excessive recruitment of fibroblasts to sites of tissue injury and unremitting extracellular …