Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

Autophagy is a dynamic process by which intracellular damaged macromolecules and
organelles are degraded and recycled for the synthesis of new cellular components. Basal …

Fluvastatin (FLV) is a statin family member that may play a role in modulating a variety of
medical disorders such as atherosclerosis and breast cancer. The present study addresses …

Glomerular diseases involving podocyte/glomerular epithelial cell (GEC) injury feature
protein misfolding and endoplasmic reticulum (ER) stress. Inositol-requiring enzyme 1α …

Background During brain aging, disturbances in neuronal phospholipid metabolism result in
impaired cognitive function and dysregulation of neurological processes. Mutations in …

Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca2+-
independent phospholipase A2γ (iPLA2γ), is addressed to the mitochondrial matrix (or …

Glomerular epithelial cell (GEC)/podocyte proteostasis is dysregulated in glomerular
diseases. The unfolded protein response (UPR) is an adaptive pathway in the endoplasmic …

Background Human glomerulonephritis (GN)—membranous nephropathy (MN), focal
segmental glomerulosclerosis (FSGS) and IgA nephropathy (IgAN), as well as diabetic …

Calcium-independent phospholipase A2γ (iPLA2γ) is localized in glomerular epithelial cells
(GECs)/podocytes at the mitochondria and endoplasmic reticulum, and can mediate release …

Statins trigger apoptotic cell death in some types of growing tumor cells in a cholesterol‐
lowering‐independent manner. Self‐nanoemulsifying delivery systems (SNEDs) are …