Clustered miRNAs and their role in biological functions and diseases

SP Kabekkodu, V Shukla, VK Varghese… - Biological …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Myocarditis

G Fung, H Luo, Y Qiu, D Yang, B McManus - Circulation research, 2016 - Am Heart Assoc
Viral myocarditis remains a prominent infectious-inflammatory disease for patients
throughout the lifespan. The condition presents several challenges including varied modes …

The quest for new approaches in myocarditis and inflammatory cardiomyopathy

S Heymans, U Eriksson, J Lehtonen… - Journal of the American …, 2016 - jacc.org
Myocarditis is a diverse group of heart-specific immune processes classified by clinical and
histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with …

Regulatory RNAs in heart failure

CPC Gomes, B Schroen, GM Kuster, EL Robinson… - Circulation, 2020 - Am Heart Assoc
Cardiovascular disease is an enormous socioeconomic burden worldwide and remains a
leading cause of mortality and disability despite significant efforts to improve treatments and …

A guide to miRNAs in inflammation and innate immune responses

C Nejad, HJ Stunden, MP Gantier - The FEBS journal, 2018 - Wiley Online Library
The discovery of micro RNA s (miRNAs) in the early 1990's has revolutionized our thinking
of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every …

MicroRNA-221/222 family counteracts myocardial fibrosis in pressure overload–induced heart failure

R Verjans, T Peters, FJ Beaumont, R van Leeuwen… - …, 2018 - Am Heart Assoc
Pressure overload causes cardiac fibroblast activation and transdifferentiation, leading to
increased interstitial fibrosis formation and subsequently myocardial stiffness, diastolic and …

[HTML][HTML] Potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers for diseases

J Song, Y Ouyang, J Che, X Li, Y Zhao, K Yang… - Frontiers in …, 2017 - frontiersin.org
microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base
pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the …

The role of the transcription factor Ets1 in carcinoma

J Dittmer - Seminars in cancer biology, 2015 - Elsevier
Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …

Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: review of the literature

J Verdonschot, M Hazebroek, J Merken… - European journal of …, 2016 - Wiley Online Library
Over the last decade, parvovirus B19 (B19V) has frequently been linked to the pathogenesis
of myocarditis (MC) and its progression towards dilated cardiomyopathy (DCM). The exact …

Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-κB p65 signal pathway and protects mice from …

T Liu, M Zhang, H Niu, J Liu, MA Ruilian… - International journal of …, 2019 - Elsevier
Inflammation plays a crucial role in regulating cardiomyopathy and injuries of coxsackievirus
B3 (CVB3)-induced viral myocarditis (VM). It has been reported that Astragalus …