Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively
termed mitochondrial quality control mechanisms, including fusion and fission, degradation …

Nix is a membrane‐anchored outer mitochondrial protein that induces mitophagy. While Nix
has an LC3‐interacting (LIR) motif that binds to ATG8 proteins, it also contains a minimal …

Mitochondria produce adenosine triphosphate and potentially contribute to proinflammatory
responses and cell death. Mitophagy, as a conservative phenomenon, scavenges waste …

Mitophagy preserves overall mitochondrial fitness by selectively targeting damaged
mitochondria for degradation. The regulatory mechanisms that prevent PTEN-induced …

Whole-exome sequencing of two unrelated kindreds with systemic autoimmune disease
featuring antinuclear antibodies with IgG4 elevation uncovered an identical ultrarare …

Chronic cerebral hypoperfusion leads to sustained demyelination and a unique response of
microglia. Triggering receptor expressed on myeloid cells 2 (Trem2), which is expressed …

Autophagy initiation is regulated by the ULK1 kinase complex. To gain insights into functions
of the holo-complex, we generated a deep interactome by combining affinity purification-and …

TNIP1 has been increasingly recognized as a security check to finely adjust the rate of
mitophagy by disrupting the recycling of the Unc-51–like kinase complex during …

T cells are pivotal in the adaptive immune defense, necessitating a delicate balance
between robust response against infections and self-tolerance. Their activation involves …

The overactivity of keratinocyte cytoplasmic signaling contributes to several cutaneous
inflammatory and immune pathologies. An important emerging complement to proteins …