More and more people worldwide are affected by severe eye diseases eventually leading to
visual impairment or blindness. In most cases, the treatment involves the application of …

Polymeric nanofibers can be produced using methods such as electrospinning, phase
separation, and self-assembly, and the fiber composition, diameter, alignment, degradation …

The utility of stem cells and their progeny in adult transplantation models has been limited by
poor survival and integration. We designed an injectable and bioresorbable hydrogel blend …

The developmental pathway of the neural retina (NR) and retinal pigment epithelium (RPE)
has been revealed by extensive research in mice. However, the molecular mechanisms …

Diseases and injuries of the central nervous system (CNS) including those in the brain,
spinal cord and retina are devastating because the CNS has limited intrinsic regenerative …

Regenerative strategies for retinal degenerative diseases are limited by poor cellular
survival, distribution and integration after transplantation to the sub-retinal space. To …

Purpose The production of functional retinal pigment epithelium (RPE) cells from human
embryonic (hESCs) and human induced pluripotent stem cells (hiPSCs) in defined and xeno …

Recent advances in induced pluripotent stem cell (iPSC) technology have paved the way for
the production of patient-specific neurons that are ideal for autologous cell replacement for …

5,589,376 A 12/1996 Anderson et a1......... 435/240.2 5,670,483 A* 9/1997 zhang et
31'""""""""" 514/14 Cells derivedfromhumanumbilical cords are disclosedalong 5,677,181 A …

Retinal progenitor cells (RPCs) are multipotent central nervous system precursors that give
rise to all of the cell types of the retina during development. Several groups have reported …