Systematic evaluation of the impact of genetic variants is critical for the study and treatment
of human physiology and disease. While specific mutations can be introduced by genome …

Summary Single-cell (sc) RNA-seq, together with RNA velocity and metabolic labeling,
reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …

The ability to manufacture human hematopoietic stem cells (HSCs) in the laboratory holds
enormous promise for cellular therapy of human blood diseases. Several differentiation …

In this issue of Blood, Mende et al 1 apply single cell sequencing and functional studies to
characterize human hematopoietic stem and progenitor cells (HSPCs) isolated from …

The fields of statistical physics and single-cell genomics have traditionally evolved
independently, each contributing unique insights to their respective domains. However …

Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of
hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature …