Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Mesenchymal stem cells (MSCs) are multipotent cells that represent a promising source for
regenerative medicine. MSCs are capable of osteogenic, chondrogenic, adipogenic and …

Osteoarthritis is one of the leading causes of pain and disability in the aged population due
to articular cartilage damage. This warrants investigation of signaling mechanisms that could …

Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

Osteoarthritis (OA) is an age-related disease, characterized by cartilage degeneration. The
pathogenesis of OA is complicated and the current therapeutic approaches for OA are …

Large bone defects cannot form a callus and exhibit high complication rates even with the
best treatment strategies available. Tissue engineering approaches often use scaffolds …

Neural crest cells (NCCs) are multipotent stem cells that can differentiate into multiple cell
types, including the osteoblasts and chondrocytes, and constitute most of the craniofacial …

The stem cells that safeguard synovial joints in adulthood are undefined. Studies on
mesenchymal stromal/stem cells (MSCs) have mainly focused on bone marrow. Here we …