Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …

Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

Patients with rheumatoid arthritis can be divided into two major subsets characterized by the
presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of …

The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …

Chemokines are small proteins that control several tissue functions, including cell
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …

A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how
systemic autoimmunity progresses to joint-specific inflammation. In patients with seropositive …

There is burgeoning interest in the interaction between the immune and nervous systems.
Pain is mediated by primary sensory neurons (nociceptors) that can respond to a variety of …

Nociceptive pain results from the detection of intense or noxious stimuli by specialized high-
threshold sensory neurons (nociceptors), a transfer of action potentials to the spinal cord …

Objective An interesting and so far unexplained feature of chronic pain in autoimmune
disease is the frequent disconnect between pain and inflammation. This is illustrated well in …

A cardinal feature of inflammation is heightened pain sensitivity at the site of the inflamed
tissue. This results from the local release by immune and injured cells of nociceptor …