Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Abstract β-catenin is the key transducer of the canonical Wnt signaling. Aberrant activation of
β-catenin has been tightly connected to the initiation and progression of various cancers …

SUMOylation is a post-translational modification that has emerged in recent decades as a
mechanism involved in controlling diverse physiological processes and that is essential in …

Aberrant SUMOylation contributes to the progression of hepatocellular carcinoma (HCC), yet
the molecular mechanisms have not been well elucidated. RING-type E3 ubiquitin ligase …

SUMO proteases or deSUMOylases regulate the lifetime of SUMO-conjugated targets in the
cell by cleaving off the isopetidic bond between the substrate and the SUMO modifier, thus …

Small ubiquitin-like modifier (SUMO), a critical regulatory modification protein, is involved in
various biological processes, such as gene expression, genome maintenance and DNA …

Stem cells with the capacity of self-renewal and differentiation play pivotal roles in normal
tissues and malignant tumors. Whereas stem cells are supposed to be genetically identical …

Background Estrogen plays a crucial role in the tumorigenesis of breast cancer (BC), and
epigenetic modification by SUMOylation is essential for cancer development. However, the …

Long, noncoding RNAs (lncRNAs) are indispensable for normal cell physiology and,
consequently, are tightly regulated in human cells. Yet, unlike mRNA, substantially less is …

Triple‑negative breast cancer (TNBC) is a highly aggressive tumour subtype associated with
poor prognosis. The function of leucine‑rich repeat‑containing protein 15 (LRRC15), a …