In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …

The discovery of organic ligands that bind specifically to proteins is a central problem in
chemistry, biology, and the biomedical sciences. The encoding of individual organic …

DNA-encoded chemical libraries (DECLs) are collections of organic compounds that are
individually linked to different oligonucleotides, serving as amplifiable identification …

Highlights•DNA-encoded chemical libraries: powerful means for hit identification in
pharma.•Link between the chemical building block and an amplifiable genetic …

DNA-encoded libraries (DELs) are collections of small molecules covalently attached to
amplifiable DNA tags carrying unique information about the structure of each library …

DNA-encoded combinatorial libraries are increasingly being used as tools for the discovery
of small organic binding molecules to proteins of biological or pharmaceutical interest. In the …

Introduction: DNA-encoded chemical libraries (DELs) have come of age and emerged to
become a powerful technology platform for ligand discovery in biomedical research and …

The identification of bioactive compounds is a crucial step toward development of probes for
chemical biology studies. Screening of DNA-encoded small molecule libraries (DELs) has …

DNA‐encoded chemical libraries (DECLs) are pools of DNA‐tagged small molecules that
enable facile screening and identification of bio‐macromolecule binders. The successful …

The incorporation of the isoindole core into the DNA-encoded chemical library is highly
desirable for the great potential pharmacological characters exampled by molecules like …