Fibrosis of visceral organs such as the lungs, heart, kidneys and liver remains a major cause
of morbidity and mortality and is also associated with many other disorders, including cancer …

The extracellular matrix (ECM) exists as a dynamic network of biophysical and biochemical
factors that maintain tissue homeostasis. Given its sensitivity to changes in the intra-and …

Microenvironmental factors are known fundamental regulators of the phenotype and
aggressiveness of glioblastoma (GBM), the most lethal brain tumor, characterized by fast …

In recent years, extensive research has uncovered crucial regulatory roles for the
extracellular matrix (ECM) in regulating autophagy. Autophagy is a ubiquitous and highly …

It is estimated that 90% of deaths from food poisoning in China can be attributed to Amanita
poisoning, whose main toxin is α-amanitin. Studies showed that apoptosis plays a critical …

Simple Summary The eminent rise of extracellular matrix constituents, chiefly hailing from
the proteoglycan gene family, has revolutionized our understanding of how intracellular …

Angelman syndrome (AS) is a rare neurogenetic disorder caused by UBE3A deficiency and
characterized by severe developmental delay, cognitive impairment, and motor dysfunction …

Mutations in the genes encoding the major collagen VI isoform, COL6A1, COL6A2 and
COL6A3, are responsible for the muscle disorders Bethlem myopathy and Ullrich congenital …

Pterostilbene (Pt) is a potentially beneficial plant phenol. In contrast to many other natural
compounds (including the more celebrated resveratrol), Pt concentrations producing …

Collagen VI and collagen XII are structurally complex collagens of the extracellular matrix
(ECM). Like all collagens, type VI and XII both possess triple-helical components that …