CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances

KM Maalej, M Merhi, VP Inchakalody, S Mestiri… - Molecular Cancer, 2023 - Springer
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …

[HTML][HTML] Antibody therapeutics and immunoregulation in cancer and autoimmune disease

M Yasunaga - Seminars in cancer biology, 2020 - Elsevier
Cancer and autoimmune disease are closely related, and many therapeutic antibodies are
widely used in clinics for the treatment of both diseases. Among them, the anti-CD20 …

Stromal modulation and treatment of metastatic pancreatic cancer with local intraperitoneal triple miRNA/siRNA nanotherapy

Y Xie, Y Hang, Y Wang, R Sleightholm, DR Prajapati… - ACS …, 2020 - ACS Publications
Nanomedicines achieve tumor-targeted delivery mainly through enhanced permeability and
retention (EPR) effect following intravenous (IV) administration. Unfortunately, the EPR effect …

[HTML][HTML] STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer

SJ Lee, H Yang, WR Kim, YS Lee, WS Lee… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Peritoneal carcinomatosis is a fatal clinical presentation of colon cancer,
characterized by unresponsiveness to conventional anticancer therapies, including immune …

Immune reprogramming precision photodynamic therapy of peritoneal metastasis by scalable stem-cell-derived extracellular vesicles

A Pinto, I Marangon, J Méreaux, A Nicolás-Boluda… - ACS …, 2021 - ACS Publications
The dissemination of tumor metastasis in the peritoneal cavity, also called peritoneal
metastasis (PM) or carcinomatosis, represents a late stage of gastrointestinal and …

Advances in the management of peritoneal malignancies

V Kepenekian, A Bhatt, J Peron, M Alyami… - Nature Reviews …, 2022 - nature.com
Peritoneal surface malignancies (PSMs) are usually associated with a poor prognosis.
Nonetheless, in line with advances in the management of most abdominopelvic metastatic …

Treatment of peritoneal metastasis with pressurized intraperitoneal aerosol chemotherapy: results from the prospective PIPAC-OPC2 study

M Graversen, S Detlefsen, AP Ainsworth… - Annals of Surgical …, 2023 - Springer
Abstract Background Pressurized Intraperitoneal Aerosol chemotherapy (PIPAC) is a local
treatment for peritoneal metastasis (PM). Prospective data are scarce and evaluation of …

Tumor-selective immune-active mild hyperthermia associated with chemotherapy in colon peritoneal metastasis by photoactivation of fluorouracil–gold nanoparticle …

V Mulens-Arias, A Nicolás-Boluda, A Pinto… - ACS …, 2021 - ACS Publications
Peritoneal metastasis (PM) is considered as the terminal stage of metastatic colon cancer,
with still poor median survival rate even with the best recent chemotherapy treatment. The …

Predicting peritoneal dissemination of gastric cancer in the era of precision medicine: molecular characterization and biomarkers

Y Chen, Q Zhou, H Wang, W Zhuo, Y Ding, J Lu, G Wu… - Cancers, 2020 - mdpi.com
Gastric cancer (GC) is a leading cause of worldwide cancer-related death. Being a highly
heterogeneous disease, the current treatment of GC has been suboptimal due to the lack of …

Update for advance CAR-T therapy in solid tumors, clinical application in peritoneal carcinomatosis from colorectal cancer and future prospects

S Qian, P Villarejo-Campos, I Guijo… - Frontiers in …, 2022 - frontiersin.org
Latest advances in the field of cancer immunotherapy have developed the (Chimeric
Antigen Receptor) CAR-T cell therapy. This therapy was first used in hematological …