Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Autophagic dysregulation has been suggested in a broad range of neurodegenerative
diseases including age-related macular degeneration (AMD). To test whether the autophagy …

Age‐related macular degeneration (AMD) is a progressive degenerative disease that is the
leading cause of vision loss in the elderly population. Degeneration/dysregulation of the …

Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous
physiological processes, including metabolism, post-translational protein modification, and …

Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …

Mitochondria undergo dynamic fusion/fission, biogenesis and mitophagy in response to
stimuli or stresses. Disruption of mitochondrial homeostasis could lead to cell senescence …

Lipofuscin granules enclose mixtures of cross-linked proteins and lipids in proportions that
depend on the tissue analyzed. Retinal lipofuscin is unique in that it contains mostly lipids …