The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial …

Mitochondria supply cells with energy in the form of ATP, guide apoptosis, and contribute to
calcium buffering and reactive oxygen species production. To support these diverse …

All cells release nucleotides and are in one way or another involved in local autocrine and
paracrine regulation of organ function via stimulation of purinergic receptors. Significant …

Mechanical forces associated with fluid flow and/or circumferential stretch are sensed by
renal epithelial cells and contribute to both adaptive or disease states. Non‐selective stretch …

Polycystins are a family of eight-transmembrane proteins united by sequence homology.
The name stems from the identification of mutations in genes encoding polycystin-1 and-2 in …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

Autosomal recessive polycystic kidney disease (ARPKD) is characterized by the progressive
dilatation of collecting ducts, the nephron segments responsible for the final renal regulation …

The kidney is a remarkable organ that accomplishes the challenge of removing waste from
the body and simultaneously regulating electrolyte and water balance. Pro-urine flows …

The importance of mechanotransduction for physiological systems is becoming increasingly
recognized. The effect of mechanical stimulation is well studied in organs and tissues, for …

The primary cilium is an extraordinary organelle. For many years, it had the full attention of
only a few dedicated scientists fascinated by its uniqueness. Unexpectedly, after decades of …