ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Monogenic diabetes gave us simplified models of complex molecular processes occurring
within β-cells, which allowed to explore the roles of numerous proteins from single protein …

Objective CEL-related maturity-onset diabetes of the young (CEL-MODY, MODY8) is a
special type of monogenetic diabetes caused by mutations in the carboxyl-ester lipase …

Context Maturity onset diabetes of the young, type 8 (MODY8) is associated with mutations
in the CEL gene, which encodes the digestive enzyme carboxyl ester lipase. Several …

Background & aims The CEL gene encodes the digestive enzyme carboxyl ester lipase.
CEL-HYB1, a hybrid allele of CEL and its adjacent pseudogene CELP, is a genetic variant …

Background & Aims A hybrid allele that originated from homologous recombination between
CEL and its pseudogene (CELP), CEL-HYB1 increases the risk of chronic pancreatitis (CP) …

Introduction Mutations of CEL gene were first reported to cause a new type of maturity-onset
diabetes of the young (MODY) denoted as MODY8 and then were also found in patients with …

Abstract Background/Objective Mutation-induced misfolding of digestive enzymes has been
shown to cause chronic pancreatitis. Recently, heterozygous pancreatic lipase (PNLIP) …

The human genome contains more than one million tandem repeats (TRs), DNA sequences
containing multiple approximate copies of a motif repeated contiguously. TRs account for …

The CEL gene encodes carboxyl ester lipase, a pancreatic digestive enzyme. CEL is
extremely polymorphic due to a variable number tandem repeat (VNTR) located in the last …