This review has been centralized on applications of phthalic anhydride (PA) as a valuable
and significant heterocyclic substrate in two-and multicomponent organic reactions. The …

Microwave technology has emerged as a great tool for the efficient synthesis of organic
compounds and it provides opportunities for chemists to achieve chemical transformations …

VEGF plays a crucial role in cancer development, angiogenesis and progression, principally
liver and breast cancer. It is vital to uncover novel chemical candidates of VEGFR inhibitors …

Pyridine compounds are one of the most important heterocyclic derivatives showing wide
ranges in biological and pharmacological activities. Green chemistry eliminates or reduces …

Aim: The structural optimization of our recently reported CDK9 inhibitor to furnish novel
aminopyrazolones and methylpyrazolones with improved pharmacokinetics. Materials & …

The present study illustrates conventional and microwave reactions of 5‐amino‐1, 3‐diaryl‐
pyrazole‐4‐carbonitrile derivative with phenacyl bromide under different conditions …

New pyrazolone derivatives were successfully synthesized by both microwave-assisted and
conventional techniques. Compound 3 (3-(3-Methyl-5-oxo-4, 5-dihydro-1H-pyrazol-1-yl)-3 …

Abstract Ethyl-2-cyano-2-(2-(3-nitrophenyl) hydrazono) acetate was synthesized and used
as a versatile reagent for the synthesis of different heterocyclic compounds such as …

The present work illustrates the treatment of 5-amino-1, 3-diphenyl-1H-pyrazole-4-
carbonitrile (1) with maleic, phthalic anhydrides, acetyl chloride, and benzene sulfonyl …

The 2-Aminonicotinonitrile derivative was reacted with different bi-functional reagents such
as formamide, thiourea, acetic anhydride, and phthalic anhydride under optimized …