Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

Importance There are currently no proven treatments to reduce the risk of mild cognitive
impairment and dementia. Objective To evaluate the effect of intensive blood pressure …

Importance The benefit of blood pressure lowering for the prevention of dementia or
cognitive impairment is unclear. Objective To determine the association of blood pressure …

As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

Cognitive function is an important component of aging and predicts quality of life, functional
independence, and risk of institutionalization. Advances in our understanding of the role of …

Importance The effect of intensive blood pressure lowering on brain health remains
uncertain. Objective To evaluate the association of intensive blood pressure treatment with …