Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell
cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's …

Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …

Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

Defining the interplay between the genetic events and microenvironmental contexts
necessary to initiate tumorigenesis in normal cells is a central endeavour in cancer biology …

Mechanical signals are increasingly recognized as overarching regulators of cell behaviour,
controlling stemness, organoid biology, tissue development and regeneration. Moreover …

Cells respond to both chemical and mechanical cues present within their microenvironment.
Various mechanical signals are detected by and transmitted to the cells through …

The process in which locally confined epithelial malignancies progressively evolve into
invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a …

This review summarizes the roles of CAFs in forming a “cancerized” fibrotic stroma favorable
to tumor initiation and dissemination, in particular highlighting the functions of the …

Simple Summary This review takes the extracellular matrix (ECM) as the starting point, and
describes its influence and related mechanisms on the biological behavior of pancreatic …