Organoiridium-catalyzed bioorthogonal chemistry

D Chauhan, P Prasad, PK Sasmal - Coordination Chemistry Reviews, 2024 - Elsevier
Abstract “Bioorthogonal chemistry” refers to chemical reactions between functional groups
not generally present in biological systems and can occur under physiological conditions …

Multifunctional Iridium (III)–Platinum (IV) Conjugates as Potent Anticancer Theranostic Agents

A Gupta, AK Pandey, T Mondal… - Journal of Medicinal …, 2023 - ACS Publications
In this article, we report IriPlatins 1–3, a new class of heterobimetallic Ir (III)-Pt (IV)
conjugates as multifunctional potent anticancer theranostic agents. In the designed …

Unlocking Efficient High‐Order Multiphoton‐Excited Fluorescence of Metal‐Organic Framework via Octupolar Module In Situ Formation

B Li, X Yu, J Wang, H Tang, X Sun… - Advanced Functional …, 2023 - Wiley Online Library
Engineering high‐order multiphoton excited fluorescent (H‐MPEF) materials is of significant
importance for sensing, 3D optical data storage and bioimaging. However, it remains a …

Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions

AG Adegboro, IS Afolabi - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Ferroptosis is an iron-dependent form of regulated cell death characterized by glutathione
(GSH) depletion, glutathione peroxidase 4 (GPX4) inactivation, and the build-up of lipotoxic …

Dramatically Enhancing Multiphoton Harvesting Metal–Organic Frameworks for NIR-II Photocatalysis through Functional Regulation of Octupolar Molecules

L Zhang, B Li, W Duan, X Sun, Y Kai… - … Applied Materials & …, 2024 - ACS Publications
The development of effective multiphoton absorption (MPA) materials for near-infrared (NIR)
light-driven photocatalysis holds great significance. In this study, we incorporated two …

AIE-active cyclometalated iridium (III) complexes for the detection of lipopolysaccharides and wash-free imaging of bacteria

A Gautam, A Gupta, P Prasad, PK Sasmal - Dalton Transactions, 2023 - pubs.rsc.org
Infectious diseases caused by bacteria pose a major threat to human health and are
currently one of the leading causes of mortality worldwide. Therefore, the development of …

Exploring antimalarial potential: Conjugating organometallic moieties with organic fragments for enhanced efficacy

NAZ Norazmi, NH Mukhtar, L Ravindar, AS Saaidin… - Bioorganic …, 2024 - Elsevier
In the search for novel ligands with efficacy against various diseases, particularly parasitic
diseases, molecular hybridization of organometallic units into biologically active scaffolds …

Multi-functional biotinylated platinum (iv)–SAHA conjugate for tumor-targeted chemotherapy

A Gupta, PK Sasmal - Dalton Transactions, 2024 - pubs.rsc.org
The development of multi-functional Pt (IV) complexes as chemotherapeutic agents has
gained growing attention in medical oncology. However, the design of multi-functional tumor …

Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy

X Sheng, MM Wang, GD Zhang, Y Su, HB Fang… - Bioorganic …, 2024 - Elsevier
Dual suppression of oxidative phosphorylation (OXPHOS) and glycolysis can disrupt
metabolic adaption of cancer cells, inhibiting energy supply and leading to successful …

Development of Cyclometalated Iridium (III) Complexes of 2‐Phenylbenzimidazole and Bipyridine Ligands for Selective Elimination of Gram‐Positive Bacteria

A Gautam, A Gupta, P Prasad… - Chemistry–An Asian …, 2024 - Wiley Online Library
Herein, we have reported a series of cationic aggregation‐induced emission (AIE) active
iridium (III) complexes (Ir1‐Ir5) of the type [Ir (C^ N) 2 (N^ N)] Cl, wherein C^ N is a …