[HTML][HTML] Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …
Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments
HIV infection and antiretroviral therapy alter mitochondrial function, which can progressively
lead to mitochondrial damage and accelerated aging. The interaction between persistent …
lead to mitochondrial damage and accelerated aging. The interaction between persistent …
Intoxication with endogenous angiotensin II: a COVID-19 hypothesis
A Sfera, C Osorio, N Jafri, EL Diaz… - Frontiers in …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 has spread rapidly around the globe.
However, despite its high pathogenicity and transmissibility, the severity of the associated …
However, despite its high pathogenicity and transmissibility, the severity of the associated …
DNA methylation of PGC-1α is associated with elevated mtDNA copy number and altered urinary metabolites in autism spectrum disorder
S Bam, E Buchanan, C Mahony… - Frontiers in Cell and …, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is a complex disorder that is underpinned by numerous
dysregulated biological pathways, including pathways that affect mitochondrial function …
dysregulated biological pathways, including pathways that affect mitochondrial function …
Increased blood-derived mitochondrial DNA copy number in African ancestry individuals with Parkinson's disease
Introduction Altered levels of mitochondrial DNA copy number (mtDNA-CN) have been
proposed as a proxy for mitochondrial dysfunction. Following reports of mtDNA depletion in …
proposed as a proxy for mitochondrial dysfunction. Following reports of mtDNA depletion in …
Decrypting biological hallmarks of aging in people with HIV
TA Premeaux, LC Ndhlovu - Current Opinion in HIV and AIDS, 2023 - journals.lww.com
New knowledge on underlying molecular disease mechanisms impacting people aging with
HIV are reviewed. Also examined are studies that may facilitate the development and …
HIV are reviewed. Also examined are studies that may facilitate the development and …
Mitochondrial DNA: a novel indicator of active inflammation in ANCA-associated vasculitides
Objectives ANCA-associated vasculitis (AAV) includes granulomatosis with polyangiitis
(GPA) and microscopic polyangiitis (MPA). ANCA triggers neutrophil extracellular trap …
(GPA) and microscopic polyangiitis (MPA). ANCA triggers neutrophil extracellular trap …
Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort
We evaluated the prospective association of mitochondrial DNA copy number (mtDNA CN)
with markers of kidney function among a cohort of persons who inject drugs (PWID). This is a …
with markers of kidney function among a cohort of persons who inject drugs (PWID). This is a …
Mitochondrial toxicogenomics for antiretroviral management: HIV post-exposure prophylaxis in uninfected patients
Background: Mitochondrial genome has been used across multiple fields in research,
diagnosis, and toxicogenomics. Several compounds damage mitochondrial DNA (mtDNA) …
diagnosis, and toxicogenomics. Several compounds damage mitochondrial DNA (mtDNA) …
Heightened levels of plasma growth differentiation factor 15 in men living with HIV
N Agarwal, CE Ramirez Bustamante, H Wu… - Physiological …, 2022 - Wiley Online Library
Plasma biomarkers that reflect energy balance disorders in people living with HIV (PLWH)
remain limited. Growth differentiation factor 15 (GDF15) abundance in plasma of mice and …
remain limited. Growth differentiation factor 15 (GDF15) abundance in plasma of mice and …