For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

The application of nanotechnology in medicine has the potential to make a great impact on
human health, ranging from prevention to diagnosis and treatment of disease. The kidneys …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …

A general synthetic method creates a new class of covalently connected, self‐threaded,
fluorescent molecular probes with figure‐eight topology, an encapsulated deep‐red …

Background The kidney proximal convoluted tubule (PCT) reabsorbs filtered
macromolecules via receptor-mediated endocytosis (RME) or nonspecific fluid phase …

The hydroxyl radical (• OH) is shown to play a crucial role in the occurrence and progression
of acute kidney injury (AKI). Therefore, the development of a robust• OH probe holds great …

Lysosomal storage disorders (LSDs), which number over fifty, are monogenically inherited
and caused by mutations in genes encoding proteins that are involved in lysosomal function …

The endosomal system constitutes a key negotiator between the environment of a cell and
its internal affairs. Comprised of a complex membranous network, wherein each vesicle can …

Carbohydrate-binding galectins are expressed in various tissues of multicellular organisms.
They are involved in autophagy, cell migration, immune response, inflammation, intracellular …