Reverse-genetics systems are powerful tools enabling researchers to study the replication
cycle of RNA viruses, including filoviruses and other hemorrhagic fever viruses, as well as to …

Bats are natural reservoirs for a variety of emerging viruses that cause significant disease in
humans and domestic animals yet rarely cause clinical disease in bats. The co-evolutionary …

The Egyptian rousette bat (Rousettus aegyptiacus) is a natural reservoir for marburgviruses
and a consistent source of virus spillover to humans. Cumulative evidence suggests various …

The DEAD-box RNA helicase eIF4A, which is part of the heterotrimeric translation initiation
complex in eukaryotes, is an important novel drug target in cancer research because its …

Colonized Egyptian fruit bats (Rousettus aegyptiacus), originating in South Africa, were
inoculated subcutaneously with Ebola virus (EBOV). No overt signs of morbidity, mortality, or …

Transport of large viral nucleocapsids from replication centers to assembly sites requires
contributions from the host cytoskeleton via cellular adaptor and motor proteins. For the …

Ebola virus is the causative agent of a severe fever with high fatality rates in humans and
nonhuman primates. The regulation of Ebola virus transcription and replication currently is …

In the United States, filoviruses (ebolaviruses and marburgviruses) are listed as National
Institute of Allergy and Infectious Diseases (NIAID) Category A Priority Pathogens, Select …

Infection with Ebola virus (EBOV) causes hemorrhagic fever in humans with high case-
fatality rates. The EBOV-glycoprotein (EBOV-GP) facilitates viral entry and promotes viral …

Specific alterations (mutations, deletions, insertions) of virus genomes are crucial for the
functional characterization of their regulatory elements and their expression products, as …